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Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects Another lovely deforming side effect is what prednisone can do to your hair. Also known as topical corticosteroids, creams like hydrocortisone are available without a prescription to help with the redness and inflammation common with bug bites, allergies, and other rashes.. Insomnia is just another side effect that keeps you up all night! But when you start taking this medicine and continue for weeks, this can create some side effects such as Heavyweight, acne, blurred vision, fluid retention, nausea, headache, etc. If your dog has been prescribed prednisone, keep close watch for any of these reactions, especially within the first few days. Also known as topical corticosteroids, creams like hydrocortisone are available without a prescription to help with the redness and inflammation common with bug bites, allergies, and other rashes October 27, 2017. 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